Fig. 2.

Spatiotemporal progression diagrams for (A) 3 mo, (B) 6 mo, (C) 9 mo, (D) 1 yr, (E) 2 yr, (F) 3 yr, (G) 5 yr, (H) 10 yr, and (I) 15 yr after cystectomy. Sites of spread include the bone, pelvis, lung, liver, Retro, “LN (reg)”, urethra, “LN (dist)”, peritoneum, UT, brain, and adrenal gland. Pelvis refers to pelvic soft tissue, Retro to the retroperitoneum, LN (reg) to regional lymph nodes, LN (dist) to distant lymph nodes, and UT to the upper tract. Other is reserved for any infrequent metastasis that does not fall in the other major categories. Markers for a patient’s overall survival status being living, deceased, or censored are also included.