Table 2.
SNP | REF allele | ALT allele | REF allele frequencya,b | Z-scoreb | p | Directionb | I2 (p)c | Position (chr:bp) | Position within gene | Gene symbol | Distance from gene (bp) |
---|---|---|---|---|---|---|---|---|---|---|---|
rs6035856 | G | T | 0.55 | 5.329 | 9.88 × 10−8 | +++++++ | 0 (0.91) | 20:2188542 | intron | LOC388780 | – |
rs6035857 | A | C | 0.55 | 5.329 | 9.88 × 10−8 | +++++++ | 0 (0.91) | 20:2188544 | intron | LOC388780 | – |
rs6082416 | G | C | 0.55 | 5.153 | 2.56 × 10−7 | +++++++ | 0 (0.85) | 20:2195832 | downstream | LOC388780 | 2035 |
rs6137325 | G | T | 0.59 | 5.147 | 2.65 × 10−7 | +++++++ | 0 (0.91) | 20:2187943 | exon | LOC388780 | – |
rs2094530 | C | T | 0.22 | 5.098 | 3.43 × 10−7 | ?--???- | 0 (0.82) | 13:51564457 | downstream | GUCY1B2 | 4190 |
rs6047381 | C | T | 0.58 | 5.089 | 3.59 × 10−7 | +++++++ | 0 (0.84) | 20:2185357 | upstream | LOC388780 | 2217 |
rs6137326 | C | T | 0.59 | 5.083 | 3.72 × 10−7 | +++++++ | 0 (0.91) | 20:2187944 | exon | LOC388780 | – |
rs6132418 | A | T | 0.58 | 5.08 | 3.78 × 10−7 | +++++++ | 0 (0.85) | 20:2186281 | upstream | LOC388780 | 1293 |
aAverage allele frequency computed for reference (REF) alleles over all the datasets analyzed.
bAllele frequencies, meta-analysis Z-scores, and directions of effect refer to REF alleles. Directions of effect are reported for each single dataset analyzed, in the following order: AGS, Finland, France, Holland, Hungary, ENall1, ENall2. “+” means that the major allele is the risk allele, while “?” indicates that the variant was not tested in the corresponding dataset.
cI2 test for heterogeneity of genetic effect across datasets (the closer to “0”, the more homogenous is the genetic effect).