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. 2020 Aug 17;26(7):2929–2942. doi: 10.1038/s41380-020-00859-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — All behaviours were measured in WT, Grin1^KD, and Grin1^RESCUE mice starting at PD98. a Time course and b total distance travelled (cm) in open field (OF) test. One-way ANOVA (total, effect of genotype F_2,126 = 156.3, p < 0.0001), Bonferroni post hoc. c Habituation index (time to reach half maximal activity) in OF test. One-way ANOVA, effect of genotype, F_2,125 = 29.38, p < 0.0001, Bonferroni post hoc. d Stereotypy number in OF test. One-way ANOVA, effect of genotype, F_2,126 = 382.7, p < 0.0001, Bonferroni post hoc. e Percent inhibition of startle response (pre-pulse inhibition, PPI). Shown on graph, Grin1^KD vs. Grin1^RESCUE, two-way ANOVA, effect of genotype—F_2,60 = 16.65, p < 0.0001; genotype × decibel—F_4,120 = 3.526, p = 0.0093, Bonferroni post hoc. f Acoustic startle response (ASR). One-way ANOVA, effect of genotype, F_2,60 = 8.913, p = 0.0004, Bonferroni post hoc. g Time to reach goal zone (seconds; max 300 s) measured in puzzle box paradigm. Shown on graph, ^#WT vs. Grin1^RESCUE; *Grin1^KD vs. Grin1^RESCUE. Two-way ANOVA, effect of genotype: F_2,64 = 66.98, p < 0.0001, Bonferroni post hoc. n values: WT—21, Grin1^KD—25, Grin1^RESCUE—21. h Total time spent, i time per visit and j social discrimination index in zones during 10 min modified three chamber social test. One-way ANCOVA, there is an effect of genotype after controlling for locomotor activity: (time in social zone) F_2,59 = 4.707, p = 0.013, (time/visit) F_2,59 = 4.424, p = 0.016, (discrimination index) F_2,59 = 3.161, p = 0.050, Bonferroni post hoc. k % time spent in open arms and l number of visits per arm in the elevated plus maze (EPM). One-way ANCOVA, there is an effect of genotype after controlling for locomotor activity: (% time spent in open arms) F_2,59 = 280.024, p < 0.001, (number of visits in the open arm) F_2,59 = 134.631, p < 0.001, Bonferroni post hoc. All data shown as mean ± SEM, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, ns not significant.