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. 2020 Aug 17;26(7):2929–2942. doi: 10.1038/s41380-020-00859-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — All behaviours were measured in WT, Grin1^KD, and Grin1^RESCUE mice starting at PD126, following intervention at either PD21 (left), or PD42 (right). a, c Time-course and b, d total distance travelled (cm) in open field (OF) test. One-way ANOVA, total distance travelled, effect of genotype: (PD21) F_2,28 = 62.53, p < 0.0001, (PD42) F_2,125 = 202.7, p < 0.0001, Bonferroni post hoc. e, g Acoustic startle response (ASR). One-way ANOVA, effect of genotype, (PD21) F_2,28 = 2.249, p = 0.1242, (PD42) F_2,61 = 6.975, p = 0.0019, Bonferroni post hoc. f, h Percent time spent in open arms in the elevated plus maze (EPM). One-way ANOVA, effect of genotype, (PD21) F_2,28 = 219.1, p < 0.0001, (PD42) F_2,61 = 210.9, p < 0.0001, Bonferroni post hoc. All data shown as mean ± SEM, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, ns not significant.