. 2021 Apr 8;26(7):2776–2804. doi: 10.1038/s41380-021-01061-w

Table 1.

Demographics of cohorts used.

	Number of subjects	Gender	Diagnosis	Ethnicity	Age Mean (SD)	T-test for age
Discovery
Discovery cohort -within-subject changes in mood (SMS-7)	44 (with 134 visits)	Male = 30 Female = 14	BP = 14 MDD = 8 SZA = 5 SZ = 6 PTSD = 8 MOOD = 2	EA = 33 AA = 9 Asian = 1 Hispanic=1	All = 50.76 (6.48)
Validation
Independent validation cohort -clinically severe depression (HAMD ≥ 22)	30	Male = 23 Female = 7	BP = 12 MDD = 12 SZA = 2 PTSD = 3 PSYCH = 1	EA = 27 AA = 2 Asian = 1	All = 49.42 (7.06)
Independent validation cohort -clinically severe mania (YMRS ≥ 20)	17	Male = 16 Female = 1	BP = 8 SZA = 6 SZ = 2 PSYCH = 1	EA = 11 AA = 6	All = 48.25 (8.21)
Testing
Independent testing cohort State predictions Low Mood (SMS-7 ≤ 40)	190	Male = 153 Female = 37	BP = 52 MDD = 30 SZA = 48 SZ = 36 PTSD = 16 MOOD = 5 PSYCH = 3	EA = 118 AA = 69 Hispanic= 2 Mixed = 1	All = 50.52 (8.58) Low mood = 49 (n = 87) Others = 50.88 (n = 359	T-test for age between low mood vs. Others 0.10469
Independent testing cohort State predictions Clinical Depression(HAMD ≥ 22)	226	Male = 181 Female = 45	BP = 74 MDD = 39 SZA = 48 SZ = 36 PTSD = 21 MOOD = 5 PSYCH = 3	EA = 156 AA = 66 Asian = 1 Hispanic= 2 Mixed = 1	All = 46.71 (9.42) Clinical depression = 44.4 (n = 40) Others = 46.9 (n = 445)	T-test for age between clinical depression vs. others 0.177087984
Independent testing cohort Trait predictions Hospitalizations with Depression First year following initial visit	147	Male = 130 Female = 17	BP = 37 MDD = 27 SZA = 32 SZ = 33 PTSD = 13 MOOD = 3 PSYCH = 2	EA = 90 AA = 54 Mixed = 1 Hispanic = 2	All = 47.13 (9.38) Hosp with Depression = 46.58 (n = 50) Others = 47.23 (n = 282)	T-test for age between hosp with depression vs. others 0.701909278
Independent testing cohort Trait predictions Hospitalizations with Depression All future years following initial visit	170	Male = 150 Female = 20	BP = 41 MDD = 29 SZA = 40 SZ = 39 PTSD = 14 MOOD = 5 PSYCH = 2	EA = 102 AA = 65 Mixed = 1 Hispanic = 2	All = 49.4 (9.78) Hosp with depression = 49.3 (n = 127) Others = 49.4 (n = 282)	T-test for age between hosp with depression vs. others 0.93467396
Independent testing cohort State predictions High Mood (SMS-7 ≥ 60)	190	Male = 153 Female = 37	BP = 52 MDD = 30 SZA = 48 SZ = 36 PTSD = 16 MOOD = 5 PSYCH = 3	EA = 118 AA = 69 Hispanic = 2 Mixed = 1	All = 50.52 (8.58) High mood = 50.6 (n = 185) Others = 50.5 (n = 261)	T-test for age between high mood vs. others 0.877948
Independent testing cohort State predictions Clinical Mania (YMRS ≥ 20)	97	Male = 73 Female = 24	BP = 37 MDD = 13 SZA = 18 SZ = 18 PTSD = 10 MOOD = 1	EA = 72 AA = 22 Hispanic = 2 Mixed = 1	All = 39.4 (8.83) Clinical Mania=38.9 (n = 13) = 38.9 (n = 13) Others=39.4(n = 197)	T-test for age between mania vs. others 0.883113775
Independent testing cohort Trait predictions Hospitalizations with Mania First year following initial visit	147	Male = 130 Female = 17	BP = 37 MDD = 27 SZA = 32 SZ = 33 PTSD = 13 MOOD = 3 PSYCH = 2	EA = 90 AA = 54 Mixed = 1 Hispanic = 2	All = 47.13 (9.38) Hosp with Mania = 45.5 (n = 11) Other = =47.2 (n = 321)s = 47.2 (n = 321)	T-test for age between hosp with mania vs. others 0.588179
Independent testing cohort Trait predictions Hospitalizations with Mania All future years following initial visit	117	Male = 102 Female = 15	BP = 34 MDD = 17 SZA = 26 SZ = 26 PTSD = 11 MOOD = 2 PSYCH = 1	EA = 74 AA = 40 Mixed = 1 Hispanic = 2	All=44.39 (9.01) Hosp with Mania = 43.7(n = 37) Others = 44.5 (n = 220)	T-test for age between hosp with mania vs. others 0.692290398

Number of subjects

Gender

Diagnosis

Ethnicity

Age
Mean
(SD)

T-test for age

Discovery

Discovery cohort

-within-subject changes in mood (SMS-7)

(with 134 visits)

Male = 30

Female = 14

BP = 14

MDD = 8

SZA = 5

SZ = 6

PTSD = 8

MOOD = 2

EA = 33

AA = 9

Asian = 1

Hispanic=1

All = 50.76 (6.48)

Validation

Independent validation cohort

-clinically severe depression

(HAMD ≥ 22)

Male = 23

Female = 7

BP = 12

MDD = 12

SZA = 2

PTSD = 3

PSYCH = 1

EA = 27

AA = 2

Asian = 1

All = 49.42

(7.06)

Independent validation cohort

-clinically severe mania

(YMRS ≥ 20)

Male = 16

Female = 1

BP = 8

SZA = 6

SZ = 2

PSYCH = 1

EA = 11

AA = 6

All = 48.25

(8.21)

Testing

Independent testing cohort

State predictions

Low Mood

(SMS-7 ≤ 40)

190

Male = 153

Female = 37

BP = 52

MDD = 30

SZA = 48

SZ = 36

PTSD = 16

MOOD = 5

PSYCH = 3

EA = 118

AA = 69

Hispanic= 2

Mixed = 1

All = 50.52

(8.58)

Low mood = 49 (n = 87)

Others = 50.88 (n = 359

T-test for age between low mood vs. Others 0.10469

Independent testing cohort

State predictions

Clinical Depression(HAMD ≥ 22)

226

Male = 181

Female = 45

BP = 74

MDD = 39

SZA = 48

SZ = 36

PTSD = 21

MOOD = 5

PSYCH = 3

EA = 156

AA = 66

Asian = 1

Hispanic= 2

Mixed = 1

All = 46.71

(9.42)

Clinical depression = 44.4 (n = 40)

Others = 46.9 (n = 445)

T-test for age between clinical depression vs. others 0.177087984

Independent testing cohort

Trait predictions

Hospitalizations with Depression

First year following initial visit

147

Male = 130 Female = 17

BP = 37

MDD = 27

SZA = 32

SZ = 33

PTSD = 13

MOOD = 3

PSYCH = 2

EA = 90

AA = 54

Mixed = 1

Hispanic = 2

All = 47.13

(9.38)

Hosp with Depression = 46.58 (n = 50)

Others = 47.23 (n = 282)

T-test for age between hosp with depression vs. others

0.701909278

Independent testing cohort

Trait predictions

Hospitalizations with Depression

All future years following initial visit

170

Male = 150 Female = 20

BP = 41

MDD = 29

SZA = 40

SZ = 39

PTSD = 14

MOOD = 5

PSYCH = 2

EA = 102

AA = 65

Mixed = 1

Hispanic = 2

All = 49.4

(9.78)

Hosp with depression = 49.3 (n = 127)

Others = 49.4 (n = 282)

T-test for age between

hosp with depression vs. others

0.93467396

Independent testing cohort

State predictions High Mood

(SMS-7 ≥ 60)

190

Male = 153

Female = 37

BP = 52

MDD = 30

SZA = 48

SZ = 36

PTSD = 16

MOOD = 5

PSYCH = 3

EA = 118

AA = 69

Hispanic = 2

Mixed = 1

All = 50.52

(8.58)

High mood = 50.6 (n = 185)

Others = 50.5 (n = 261)

T-test for age between high mood vs. others

0.877948

Independent testing cohort

State predictions

Clinical Mania

(YMRS ≥ 20)

Male = 73

Female = 24

BP = 37

MDD = 13

SZA = 18

SZ = 18

PTSD = 10

MOOD = 1

EA = 72

AA = 22

Hispanic = 2

Mixed = 1

All = 39.4

(8.83)

Clinical Mania=38.9 (n = 13)

= 38.9 (n = 13)

Others=39.4(n = 197)

T-test for age between mania vs. others

0.883113775

Independent testing cohort

Trait predictions

Hospitalizations with Mania

First year following initial visit

147

Male = 130 Female = 17

BP = 37

MDD = 27

SZA = 32

SZ = 33

PTSD = 13

MOOD = 3

PSYCH = 2

EA = 90

AA = 54

Mixed = 1

Hispanic = 2

All = 47.13

(9.38)

Hosp with Mania

= 45.5 (n = 11)

Other = =47.2 (n = 321)s

= 47.2 (n = 321)

T-test for age between hosp with mania

vs. others

0.588179

Independent testing cohort

Trait predictions

Hospitalizations with Mania

All future years following initial visit

117

Male = 102 Female = 15

BP = 34

MDD = 17

SZA = 26

SZ = 26

PTSD = 11

MOOD = 2

PSYCH = 1

EA = 74

AA = 40

Mixed = 1

Hispanic = 2

All=44.39

(9.01)

Hosp with Mania

= 43.7(n = 37)

Others

= 44.5 (n = 220)

T-test for age between hosp with

mania vs. others

0.692290398

BP bipolar, MDD major depressive disorder, SZA schizoaffective disorder, SZ schizophrenia, PTSD post-traumatic stress disorder, MOOD mood disorder nos, PSYCH psychosis nos.