Table 5.
Correlation between PD-L1-antibody, clone 22C3 and the four budding/TIL groups
| PD-L1 IHC, clone 22C3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Overall | TPS | IC | |||||||
| Budding/TIL groups | Positive (n/%) | Negative (n/%) | p value | Positive (n/%) | Negative (n/%) | p value | Positive (n/%) | Negative (n/%) | p value |
|
Low buds/high TILs (n = 129) |
60 (46.5) | 69 (43.5) | < 0.001 | 18 (14.0) | 111 (86.0) | 0.002 | 54 (41.9) | 75 (58.1) | < 0.001 |
|
Low buds/low TILs (n = 128) |
28 (22.0) | 99 (78.0) | 3 (2.4) | 124 (97.6) | 26 (20.5) | 101 (79.5) | |||
|
High buds/high TILs (n = 42) |
11 (26.2) | 31 (73.8) | 3 (7.1) | 39 (92.9) | 10 (23.8) | 32 (76.2) | |||
| High buds/low TILs (n = 48) | 6 (12.5) | 42 (87.5) | 1 (2.1) | 47 (97.9) | 6 (12.5) | 42 (87.5) | |||
Statistically significant values are indicated in italics
IHC immunohistochemistry, TPS tumor positivity score, IC immune cell score, TILs tumor-infiltrating lymphocytes