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. 2021 Apr 20;268(11):4321–4331. doi: 10.1007/s00415-021-10563-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Survival from symptom onset (time point T0). Survival analyses were performed using critical cut-off values for respiratory sleep outcomes at baseline sleep studies (time point T1). a–c Refer to patients who did not undergo non-invasive ventilation (NIV), d–f depict Kaplan-Meyer plots for patients who started enduring NIV following T1. AHI apnea hypopnea index, EMBE early morning base excess, ptcCO₂ maximum nocturnal transcutaneous CO₂ tension, X axis months, Y axis cumulative survival. p values < 0.05 were considered significant