Table 1.
Demographic data and disease characteristics in the entire study cohort and in patients stratified according to the presence of sleep-disordered breathing (SDB, columns 3 + 4) and enduring non-invasive ventilation (NIV, columns 6 + 7)
| All patients (n = 158) | SDB (n = 97) | No SDB (n = 61) | p | NIV(+) (n = 95) | NIV(−) (n = 63) | p | |
|---|---|---|---|---|---|---|---|
| Male [n/%] | 86/54.4 | 63/64.9 | 23/37.7 | 0.001# | 54/56.8 | 32/50.8 | N.S.# |
| Age at T0, [years] | 61.4 (10.9) | 63.2 (10.2) | 58.6 (11.4) | 0.009* | 62.3 (10.1) | 59.9 (12.0) | N.S.* |
| Age at T1 [years] | 63.9 (10.4) | 65.9 (9.3) | 60.9 (11.3) | 0.003* | 64.6 (9.9) | 63.9 (11.1) | N.S.* |
| Disease duration (T0–T1) [months] | 30.2 (33.4) | 31.9 (37.6) | 27.6 (28.7) | N.S.§ | 26.9 (21.7) | 35.2 (47.4) | N.S.§ |
| BMI [kg/m2] | 24.8 (4.1) | 25.3 (3.9) | 24.2 (4.4) | N.S.* | 25.3 (4.3) | 24.1 (3.8) | N.S.* |
| Deceased [n/%] | 105/66.5 | 67/69.1 | 38/62.3 | N.S.# | 71/74.7 | 34/54.0 | 0.007# |
| Bulbar onset [n/%] | 51/32.3 | 30/30.9 | 21/34.4 | N.S.# | 28/29.5 | 23/36.5 | N.S. # |
| Severe bulbar dysfunction at T1 [n/%] | 41/25.9 | 25/25.8 | 16/26.2 | N.S.# | 24.0/25.2 | 17/27.0 | N.S.# |
| ALSFRS-R total score at T1 | 35.6 (7.4) | 35.0 (7.3) | 36.5 (7.7) | N.S.§ | 35.3 (7.3) | 36.0 (7.7) | N.S.§ |
| ΔFS | 0.8 (1.0) | 0.9 (1.0) | 0.8 (0.8) | N.S.§ | 0.9 (1.1) | 0.7 (0.8) | N.S.§ |
| Medication with riluzole at T1[n/%] | 123/78.8 | 74/76.3 | 49/80.3 | N.S.# | 75/78.9 | 48/76.2 | N.S.# |
| Survival time after T0 [months] | 52.4 (40.8) | 52.5 (43.9) | 52.2 (35.8) | N.S.§ | 50.8 (31.1) | 54.8 (52.4) | N.S.§ |
| Survival time after T1 [months] | 22.1 (18.9) | 20.6 (17.7) | 24.6 (20.5) | N.S.§ | 23.8 (20.4) | 19.6 (16.1) | N.S.§ |
T0 self-reported symptom onset, T1 date of baseline sleep studies, ΔFS monthly loss on the ALS-FRS-R between T0 and T1, N.S. not significant
Numbers are depicted as mean and standard deviation (in brackets), or absolute number/percentage (in relation to the subgroup specified at the top of the columns)
p values ≤ 0.05 were considered significant
#Chi-square test
*t test
§Mann–Whitney U test