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. 2021 Oct 11;11:20131. doi: 10.1038/s41598-021-99696-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxic and hemolytic activity of peptides. (A) Cytotoxicity of DIII blocking peptides assessed by XTT test after 24 h of incubation at different concentrations. A statistically significant difference (P < 0.01, two-tailed P-value) was calculated by unpaired t-test with Welch´s correction compared to the negative control (untreated cells). None of the peptides showed significant cytotoxicity. Statistics was performed with GraphPad Prism v8.4.3. “-” – negative control (untreated hBMECs); “+” – positive control (cells treated with 0.1% Triton X-100); CP – 7-mer cyclic peptide. (B) Assessment of hemolytic activity of peptides. Suspension of sheep erythrocytes was incubated with peptides at two different concentrations. No hemolytic effect (no release of hemoglobin) of peptides was observed. “-” – negative control (untreated sheep erythrocytes); “+” – positive control (sheep erythrocytes treated with 0.1% Triton X-100); CP – 7-mer cyclic peptide.