Fig. 6. Gene expression profile (GEP), protein–protein interaction (PPI) network, and gene ontology (GO) enrichment analyses in HLA-A24-restricted CMV-pp65-specific cytotoxic T-cells (CMV-CTL) in the early phase of allo-HCT according to the donor CMV serostatus.

a A clustering heatmap of GEP using the top 100 differentially expressed genes (DEGs) between CMV-seronegative (n = 11) and -seropositive (n = 10) donors. b PPI network constructed from the top 100 DEGs which had close connections with each other. The shape size suggests the degree of centrality of the PPI network, meaning how many edges are connected to each gene node. The color heat denotes log-fold changes in individual gene expression between the CMV-seropositive vs. -seronegative donor groups. Only networks with ≥5 connections are shown. c GO and the shared genes derived from the top 200 DEGs. Each circle denotes an identified term with a P-value of <0.05 without the Bonferroni correction. The same colors mean GO terms that belong to the same GO term-tree groups. Only the names of the leading GO terms with the highest significance in each GO term-tree group are shown.