Table 3.

Association between alcohol consumption trajectories and breast cancer occurrence: total sample, by menopausal status and by body mass index in postmenopausal women.

Alcohol consumption trajectories	Controls	Cases	Model 1a OR (95% CI)	Model 2b OR (95% CI)
Total (N = 1278; 639 paired Ca/Co)
Trajectory 1	304	280	1 (ref.)	1 (ref.)
Trajectory 2	228	216	1.05 (0.80. 1.37)	1.17 (0.86. 1.58)
Trajectory 3	70	86	1.38 (0.96. 1.97)	1.44 (0.96. 2.16)
Trajectory 4	37	57	1.79 (1.12. 2.88)	2.19 (1.27. 3.77)
Premenopausal (n = 925)
Trajectory 1	217	212	1 (ref.)	1 (ref.)
Trajectory 2	151	160	1.07 (0.80. 1.43)	1.11 (0.81. 1.52)
Trajectory 3	53	68	1.35 (0.89. 2.03)	1.36 (0.88. 2.10)
Trajectory 4	26	38	1.48 (0.86. 2.52)	1.46 (0.82. 2.59)
Postmenopausal (n = 653)
Trajectory 1	186	141	1 (ref.)	1 (ref.)
Trajectory 2	117	98	1.12 (0.79. 1.58)	1.22 (0.83. 1.79)
Trajectory 3	32	38	1.66 (0.98. 2.82)	1.79 (1.02. 3.15)
Trajectory 4	17	24	1.92 (0.99. 3.72)	2.33 (1.11. 4.93)
Body mass index < 25 kg/m2 (n = 263)c
Trajectory 1	74	49	1 (ref.)	1 (ref.)
Trajectory 2	51	39	1.14 (0.66. 1.98)	1.75 (0.90. 3.38)
Trajectory 3	14	13	1.56 (0.65. 3.73)	1.79 (0.68. 4.69)
Trajectory 4	10	13	1.98 (0.80. 4.89)	3.28 (1.14. 9.39)
Body mass index ≥ 25 kg/m2 (n = 322)*
Trajectory 1	93	75	1 (ref.)	1 (ref.)
Trajectory 2	54	49	1.16 (0.71. 1.91)	1.16 (0.65. 2.05)
Trajectory 3	16	18	1.36 (0.64. 2.86)	1.42 (0.62. 3.26)
Trajectory 4	7	10	1.80 (0.65. 5.00)	1.94 (0.60. 6.25)

OR odds ratio, CI confidence interval.

^aAdjusted for age at the time of recruitment and hospital.

^bAdditionally adjusted for BMI, menopausal status, an interaction term between BMI and menopausal status, calories, age at menarche, number of children, age at first child, smoking status, educational level, chronic diseases, hormone replacement therapy use, previous benign breast lesions, family history of breast cancer, physical activity, adherence to the Mediterranean dietary pattern.

^cWomen with imputed BMI were excluded for this analysis (n = 68).