Table 2.
Effect of schizophrenia PRS (p-value threshold ≤1) on each school grade at age 12, separately for males and females as well as for all individuals.
| N | Estimate (95% CI) | t-value | p-value | ||
|---|---|---|---|---|---|
| Mathematics | All | 496 | −0.082 (−0.170 to 0.006) | −1.837 | 0.0668 |
| Females | 249 | −0.012 (−0.132 to 0.1081) | −0.195 | 0.8457 | |
| Males | 247 | −0.170 (−0.299 to −0.041) | −2.603 | 0.0098* | |
| Swedish | All | 496 | −0.033 (−0.119 to 0.054) | −0.748 | 0.4549 |
| Females | 249 | 0.030 (−0.091 to 0.152) | 0.491 | 0.6240 | |
| Males | 247 | −0.111 (−0.234 to 0.013) | −1.767 | 0.0785 | |
| History | All | 496 | −0.100 (−0.189 to −0.011) | −2.208 | 0.0278* |
| Females | 249 | −0.018 (−0.142 to 0.106) | −0.281 | 0.7788 | |
| Males | 247 | −0.195 (−0.324 to −0.066) | −2.969 | 0.0033* | |
| Biology | All | 496 | −0.077 (−0.167 to 0.013) | −1.683 | 0.0931 |
| Females | 249 | 0.042 (−0.081 to 0.165) | 0.676 | 0.4999 | |
| Males | 247 | −0.214 (−0.344 to −0.084) | −3.236 | 0.0014* | |
| Geography | All | 496 | −0.050 (−0.139 to 0.039) | −1.110 | 0.2678 |
| Females | 249 | 0.081 (−0.039 to 0.202) | 1.331 | 0.1845 | |
| Males | 247 | −0.202 (−0.332 to −0.072) | −3.061 | 0.0025* | |
| Scripture knowledge (Christianity) | All | 496 | −0.096 (−0.181 to −0.012) | −2.239 | 0.0256* |
| Females | 249 | −0.028 (−0.145 to 0.089) | −0.474 | 0.6357 | |
| Males | 247 | −0.186 (−0.308 to −0.064) | −3.005 | 0.0029* |
Bold: p < 0.008 (corrected for multiple testing across six subjects). Linear regression models included sex (when applicable), birth month, and the first 5 genetic principal components for genetic ancestry as covariates of no interest.
CI confidence interval, PRS polygenic risk score.
*p < 0.05 (uncorrected).