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. 2021 Jun 29;46(12):2170–2179. doi: 10.1038/s41386-021-01056-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — In a longitudinal study design (A, D), wild-type (WT) and transgenic (TG) rats received single daily s.c. injections of CORT (10 mg/kg) for 3 days. In first group of animals, performance of WT (B) and TG (C) rats was tested in a relatively simple novel object recognition task on Day-14 before CORT treatment and 1 Day after the last CORT injection. To avoid potential confounds of multiple repeated behavioural testing in the NOR task, another group of animals was tested on Days 1 and 21. After initial memory disruption on Day 1, WT animals (E) significantly improved DI on Day 21. In contrast, TG rats (F) didn’t show any recovery of performance. Summary of discrimination index (DI) for individuals and groups are in left and right hand panels, respectively. The # symbol stands for a statistical comparison of DI with the hypothetical no-bias value of 0.5 on the same day (one sample t test) whereas an * indicates a comparison between different days (paired t test). One symbol, p < 0.05; two symbols, p < 0.01; three symbols, p < 0.001. Values are mean ± S.E.M. % of DI.