Table 4.
GO and pathway analysis using the candidate genes associated with the multifocal and diffuse lesions.
| Phenotype | ID | Description | P adjust | Genes | Genes ratio |
|---|---|---|---|---|---|
| Multifocal | GO:0045095 | Keratin filament | 6.816E−13 | KRT73/KRT72/KRT74/KRT5/KRT75/KRT83/KRT81/KRT7/KRT80 | 9/44 |
| GO:0005882 | Intermediate filament | 1.691E−10 | KRT73/KRT72/KRT74/KRT5/KRT6B/KRT75/KRT83/KRT81/KRT7/KRT80 | 10/44 | |
| GO:0045111 | Intermediate filament cytoskeleton | 4.644E−10 | KRT73/KRT72/KRT74/KRT5/KRT6B/KRT75/KRT83/KRT81/KRT7/KRT80 | 10/44 | |
| GO:0099512 | Supramolecular fiber | 4.389E−07 | KRT73/KRT72/KRT74/KRT5/KRT6B/KRT75/KRT83/KRT81/KRT7/KRT80/MYOM1/MYL12A/MYL12B | 13/44 | |
| GO:0099081 | Supramolecular polymer | 4.389E−07 | KRT73/KRT72/KRT74/KRT5/KRT6B/KRT75/KRT83/KRT81/KRT7/KRT80/MYOM1/MYL12A/MYL12B | 13/44 | |
| GO:0099513 | Polymeric cytoskeletal fiber | 1.689E−05 | KRT73/KRT72/KRT74/KRT5/KRT6B/KRT75/KRT83/KRT81/KRT7/KRT80 | 10/44 | |
| GO:0099080 | Supramolecular complex | 2.1E−05 | KRT73/KRT72/KRT74/KRT5/KRT6B/KRT75/KRT83/KRT81/KRT7/KRT80/MYOM1/MYL12A/MYL12B | 13/44 | |
| Diffuse | bta04979 | Cholesterol metabolism | 0.016505 | NCEH1/LDLR/ANGPTL8/ANGPTL4 | 4/49 |