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. 2021 Sep 28;12:730312. doi: 10.3389/fphar.2021.730312

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Copyright © 2021 Pei, Huang, Ni, Zhang, Niu and You.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ALT attenuated the degeneration of Collagen II induced by IL-1β in mouse chondrocytes. (A) Western blotting result of Collagen II. (B) Quantification analysis of western blotting results, GAPDH was regarded as an internal control (n = 3). (C) Safranin O staining for proteoglycans deposition in each group after a 7-days incubation (scale bar 100 μm). (D) Collagen II expression was determined by immunofluorescence staining (scale bar 100 μm). #p < 0.05 vs. control group; *p < 0.05 vs. IL-1β group; **p < 0.01 vs. IL-1β group.