TABLE 3.
Improvement for the addition of MPO and TMAO to GRS in predicting risk of cardiovascuar even assessed by area under the curve.
| GRS | GRS + TMAO | GRS + MPO | GRS + TMAO + MPO | |
|---|---|---|---|---|
| 6-month death | ||||
| AUC | 0.837 (0.746-0.929) | 0.842 (0.754—0.930) | 0.852 (0.762-0.942) | 0.857 (0.770-0.944) |
| P difference | — | 0.419 | 0.187 | 0.118 |
| 6-month MACE | ||||
| AUC | 0.736 (0.632—0.840) | 0.743 (0.643-0.842) | 0.753 (0.652-0.854) | 0.760 (0.663-0.858) |
| P difference | — | 0.319 | 0.150 | 0.087 |
| 1-month death | ||||
| AUC | 0.816 (0.701—0.930) | 0.824 (0.715-0.934) | 0.818 (0.701-0.934) | 0.827 (0.715-0.938) |
| P difference | — | 0.454 | 0.551 | 0.328 |
| 1-month MACE | ||||
| AUC | 0.723 (0.589—0.858) | 0.747 (0.629-0.865) | 0.724 (0.589-0.859) | 0.747 (0.627-0.866) |
| P difference | — | 0.203 | 0.458 | 0.175 |
AUC, area under the receiver operating characteristic curve; GRS, the global registry of acute coronary events (GRACE) risk score; MACE, major adverse cardiovascular event; MPO, myeloperoxidase; TMAO, trimethylamine N-oxide.