TABLE 4.
Improvement for the addition of MPO and TMAO to GRS in predicting risk of cardiovascular event assessed by net reclassification index.
| GRS + MPO | GRS + TMAO | GRS + MPO + TMAO | ||||
|---|---|---|---|---|---|---|
| NRI (95%CI) | p-value | NRI (95%CI) | p-value | NRI (95%CI) | p-value | |
| 6-month death | 0.39 (−0.06–0.85) | 0.092 | 0.47 (0.01–0.93) | 0.050 | 0.67 (0.20–1.13) | 0.005 |
| 6-month MACE | 0.33 (−0.04–0.71) | 0.080 | 0.35 (−0.03–0.73) | 0.071 | 0.42 (0.04–0.80) | 0.032 |
| 1-month death | 0.17 (−0.27–0.62) | 0.044 | 0.62 (0.15–1.08) | 0.010 | 0.49 (0.03–0.96) | 0.037 |
| 1-month MACE | 0.28 (−0.26–0.81) | 0.310 | 0.57 (0.02–1.12) | 0.041 | 0.64 (0.09–1.19) | 0.022 |
CI, confidence interval; GRS, the global registry of acute coronary events (GRACE) risk score; MACE, major adverse cardiovascular event; MPO, myeloperoxidase; NRI, net reclassification index; TMAO, trimethylamine N-oxide.