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. 2021 Oct 11;11:20116. doi: 10.1038/s41598-021-99490-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic analysis of eCIS-related genes in Streptomyces species. eCIS-related genes are conserved among Streptomyces. (A) Organizations of eCIS-related genes that are conserved in the model Streptomyces species. (B) A phylogenetic tree of eCIS and SLP proteins. The tree was constructed based on 72 amino acid sequences of tube proteins using the neighbor-joining method. Red and black circles indicate the clades with the bootstrap values of 100 and 85–99, respectively. The evolutionary distances were computed using the p-distance method and are in the units of the number of amino acid differences per site. Afp, anti-feeding prophage; PVC, Photorhabdus virulence cassettes; MAC, metamorphosis-associated contractile structures.