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. 2021 Oct 11;11:20133. doi: 10.1038/s41598-021-99701-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Repeatability and reproducibility of voxel-wise radiomics features in test–retest data. (a) Most repeatable features are located at the top of the graphic according to CCC and (b) gamma passing rate (Γ-index). The gamma (Γ) acceptance criterion (2 mm/1%) is defined as the distance to agreement (DTA) and the maximum feature value in percent (F_max), as shown in the insert. Features were extracted with a fixed bin size of 12 and kernel radius of 1. (c) Reproducibility of voxel-wise radiomics features to feature extraction parameters (B = bin size and R = kernel radius). (d) Reproducibility of voxel-wise features computed using all combinations of feature extraction parameters.