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. 2021 Jul 20;46(12):2121–2131. doi: 10.1038/s41386-021-01096-1

Fig. 1. Effect of Systemic Administration of LY2817412 on Yohimbine-Induced Reinstatement of Alcohol Seeking in Male and Female msP Rats.

Fig. 1

A Schematic representation of the experimental timeline. B Self-administration: black circles (male) and white circles (female) represent mean number of the responses during the last 3 days of alcohol self-administration sessions. No differences were denoted in the number of active or inactive lever presses during this phase. Extinction: mean number of lever presses during the last 3 days of extinction (EXT). Compared to extinction, male (n = 10) and female (n = 10) msP rats treated with yohimbine (1.25 mg/kg; i.p.) and LY2817412 vehicle (0.0) showed a significant reinstatement of responding. Administration of LY2817412 significantly reduced yohimbine-induced reinstatement both in males and females. Previously alcohol paired active and inactive lever presses are presented in the upper and lower panels, respectively. Values represent the mean (±SEM). ###p < 0.001, difference between EXT and rats treated with yohimbine plus LY2817412 vehicle (0.0); *p < 0.05, **p < 0.01, ***p < 0.001, differences between rats treated with yohimbine and LY2817412 vehicle (0.0) and rats treated different doses of the antagonist.