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. 2021 Jul 20;46(12):2121–2131. doi: 10.1038/s41386-021-01096-1

Fig. 2. Effect of Systemic Administration of LY2817412 on Cue-Induced Reinstatement of Alcohol-Seeking in Male and Female msP Rats.

Fig. 2

A Schematic representation of the experimental timeline. B Conditioning phase: black circles (male) and white circles (female) represent the responses during the last 3 days of alcohol self-administration sessions; black squares (male) and white squares (female) represents the responses during the last 3 days of water self-administration sessions during the discrimination phases. Analysis of this phase showed a significant time × drugs interaction for the active lever presses. No differences were denoted for the inactive lever. Extinction: mean number of lever presses during the last 3 days of extinction (EXT). Compared to extinction, male (n = 8) and female (n = 10) msP rats showed a significant reinstatement of lever pressing in response to alcohol cues (S+/CS+) but not to water (S−/CS−). Administration of LY2817412 significantly reduced cue (S+/CS+) induced reinstatement of alcohol seeking. Previously alcohol paired active and inactive lever presses are presented in the upper and lower panels, respectively. Values represent the mean (±SEM). ###p < 0.001, difference between EXT and rats exposed to alcohol paired cues (S+/CS+) treated with LY2817412 vehicle (0.0); °°p < 0.01, difference in the reinstatement between male and female msP rats; ***p < 0.001, difference between rats presented with S+/CS+ and LY2817412 vehicle (0.0) and rats treated different doses of the antagonist.