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. 2021 Jun 29;46(12):2090–2100. doi: 10.1038/s41386-021-01064-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The immunoblotting results for the expression of the monomer and dimer forms of mGlu1 and mGlu5 within the PL are presented in the left panels. For direct comparison, the results for the IL are presented in the right panels. a–d In the PL, a non-significant reduction in the expression of both the dimer and monomer forms of each receptor was observed in 30WD-VEH vs. 3WD-VEH controls. Relative to 30WD-VEH rats, everolimus increased mGlu1/5 expression in rats tested on WD30. e–h Relative to 3WD-VEH controls, 30WD-VEH rats exhibited a significant increase in the IL levels of the mGlu1 monomer only. Everolimus significantly elevated IL levels of the mGlu1 dimer in rats tested on 30WD, with no other significant changes in protein expression detected in this subregion. As indicated in a, the data are presented as box plots in which the mean is represented by, the median by —, outliers are indicated by ♦’s, the box represents the interquartile range (IQR) and the error bars represent 1.5 X IQR (see d). *p < 0.05 WD3-VEH vs. WD30-VEH (incubation); ⁺p < 0.05 30WD-VEH vs. 30WD-E1.0 (Everolimus effect) as determined by Tukey–Kramer comparisons corrected for multiple comparisons.