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. 2021 Oct 11;12:5930. doi: 10.1038/s41467-021-26156-4

Fig. 6. Proposed model describing how homeostatic PM tension acts as the mechanical suppressor of cancer cell dissemination.

Fig. 6

a Proposed model to describe how cancer progression is linked to the disruption of homeostatic PM tension, leading to cancer cell dissemination via BAR proteins. b Homeostatic PM tension sustained by membrane-to-cortex attachment (MCA) can maintain a non-motile state by suppressing the assembly of BAR proteins, key regulators of both actin- and bleb-based protrusions.