Fig. 4. Frontal cortex mGlu₃ receptor knockdown induces a modest anxiolytic phenotype.

a Cre-expressing mice (green circles ♀, green squares ♂) spent more time in the open components of the elevated-zero maze than GFP controls (white circles ♀, gray squares ♂) (117.2 ± 8.4 s Cre vs 96.4 ± 5.5 s GFP, *p < 0.05, t₃₂ = 2.115, N = 16–18 mice/group). b No difference in the total number of arm crossings between GFP and Cre mice. c No difference in the proportion of time spent in the brightly lit side of a light-dark box between GFP and Cre mice. d No group difference in the number of side crossings.