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. 2021 Oct 11;11:20168. doi: 10.1038/s41598-021-99643-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Collagen area is wound-age dependent in the VLU cohort. (a) Collagen area of VLU patients were categorized based on the duration of each wound: 0–11 (n = 8), 12–23 (n = 2) and more than 24 months (n = 4). (b) Collagen area of less than 60 years old VLU patients: 0–11 (n = 3), 12–23 (n = 2) and more than 24 months (n = 3) at point of biopsy and grouped based on wound duration. Data shown as mean ± SEM. *p < 0.05, **p < 0.001.