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. 2021 Sep 28;8:725390. doi: 10.3389/fmed.2021.725390

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Copyright © 2021 Bruneau, Hundertmark, Guillot and Tacke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bile acid roles in inflammation and tissue repair modulation. TGR5 and FXR are two well-characterized bile acid receptors implicated in liver homeostasis. TGR5 activation on cholangiocytes and macrophages stimulates cell proliferation and decreases inflammatory signaling, respectively. Bile acid synthesis by hepatocytes is repressed by FXR activation. FXR, Farnesoid X-Activated Receptor; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; TGR5, also known as GPBAR1, G-protein-coupled bile acid receptor. Created with Biorender.