Table 2.

TLRs involvement in the progression of NAFLD and NASH.

	NAFLD	NASH
TLR2	↗ in HFD mouse KCs (135)	CDAA, expression by KCs increases inflammation and fibrosis, TLR2 activation is followed by inflammasome activation IL1α and IL1β (136)
TLR4	↗ in HFD mouse KCs (135) ↗ in patients biopsies (135)	↗ in patients biopsies ↗ in patients serum (137) ↗ liver expression after DSS treatment in a NASH model (138) ↗ liver expression in a NASH model (108)
TLR5	Activated in hepatocytes and adipocytes in HFD model (139) ↗ in NAFLD patients	Expression in hepatocytes has a protecting role in NASH model (140, 141)
TLR9		↗ in patients biopsies (142) ↗ liver expression after DSS treatment (138) Expression by KCs neutrophils and DCs is involved in NASH progression (143) Deletion has a protective effect in a HFD model (143)

CDAA, Choline deficient amino acid; DCs, Dendritic cells; DSS, Dextran sodium sulfate; HFD, High fat-diet; IL, Interleukin; KCs, Kupffer cells; NAFLD, Non-alcoholic fatty liver disease; NASH, Non-alcoholic steatohepatitis; TLRs, Toll like receptors; ↗, Overexpression.