Table 1.
Effects of A. graveolens seeds hexane extract (AGHE), methanol extract (AGME), and luteolin on macroscopic parameters of colitis induced by acetic acid in rats
| Groups/Dose (mg/kg) | Ulcer Area (cm2) | Ulcer Score (0-3) | Ulcer Index (0-10) | W/L Ratio (mg/cm2) |
|---|---|---|---|---|
| Sham | 0.00±0.00*** | 0.0 (0-0)** | 0.00±0.00*** | 74.33±5.09*** |
| Control | 5.94±0.32 | 3.0 (2-3) | 8.94±0.44 | 155.04±4.30 |
| AGHE100 | 4.02±1.24 | 2.0 (1-3) | 6.02±1.60 | 135.67±10.33 |
| AGHE200 | 2.49±0.82* | 1.5 (0-2)** | 3.99±1.09* | 116.91±10.58* |
| AGHE400 | 1.95±0.82** | 1.0 (0-2)* | 2.95±1.26** | 111.01±8.23** |
| AGME200 | 3.00±0.45 | 1.5 (1-2) | 4.50±0.63 | 124.75±9.14 |
| AGME400 | 2.08±0.25** | 1.0 (1-2)** | 3.08±0.41** | 110.53±8.65** |
| AGME800 | 1.16±0.55*** | 0.5 (0-2)** | 1.66±0.88*** | 104.53±8.43*** |
| Luteolin 5 | 3.46±0.83 | 1.5 (1-3) | 4.96±1.23 | 132.30±6.65 |
| Luteolin 10 | 1.76±0.76** | 1.0 (0-3)* | 2.76±1.23** | 113.53±9.38** |
| Luteolin 20 | 1.00±0.38*** | 1.0 (0-1)** | 2±0.59*** | 104.52±4.73*** |
| Prednisolone4 | 0.48±0.50*** | 0.5 (0-1)** | 0.98±0.27*** | 82.96±1.98*** |
| Mesalazine100 | 0.58±0.45*** | 1.0 (0-1)** | 1.58±0.24*** | 90.01±2.40*** |
Sham: normal rats received vehicle (2 mL/kg/day). W/L: weight/length ratio. Data are expressed as mean±S.E.M. or median (range) for scoring parameter, (n=6). *P<0.05, **P<0.01, ***P<0.001, indicate significant difference versus control group