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. 2021 Sep 28;12:732716. doi: 10.3389/fphar.2021.732716

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Copyright © 2021 Pan, Han, Xu, Peng, Bai, Zhou and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hierarchical clustering heat map of the top 25 differential metabolites selected based on t-tests/ANOVA, with the degree of change marked with red (up-regulation) and blue (down-regulation). The distance measure was set to “Euclidean” and the clustering algorithm was set to “Ward”. (A): control group, 40 μM EGCG-treated group and 80 μM EGCG-treated group; (B): control group and 40 μM EGCG-treated group; (C): control group and 80 μM EGCG-treated group. Abbreviations: R5P, Ribose-5-phosphate; 4-ImAA, 4-Imidazoleacetic acid; NAD, nicotinamide adenine dinucleotide; PEP, phosphoenolpyruvate; 2-MGA, 2-Methylglutaric Acid; GA3P, glyceraldehyde 3-phosphate; GSH, glutathione; DMG, Dimethylglycine; Aib, 2/3-Aminoisobutyric acid; alpha-KG, alpha-Ketoglutaric acid; AHA, Acetohydroxamic acid.