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. 2021 Sep 28;12:732716. doi: 10.3389/fphar.2021.732716

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Copyright © 2021 Pan, Han, Xu, Peng, Bai, Zhou and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of the modulated metabolites and potential disturbed metabolic pathways. Up-regulated metabolites detected are shown in the orange background; down-regulated metabolites detected are shown in the blue background; blank background means no statistically significant change or undetected. Abbreviations: PEP, phosphoenolpyruvate; GA3P, glyceraldehyde 3-phosphate; G6P, glucose-6-phosphate; α-KG, alpha-Ketoglutaric acid; R5P, Ribose-5-phosphate; CTP, cytidine triphosphate; PC, phosphatidylcholine; PE, phosphatidylethanolamine; HBP, hexosamine biosynthetic pathway; PPP, pentose phosphate pathway; TCA, tricarboxylic acid.