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. Author manuscript; available in PMC: 2021 Oct 12.
Published in final edited form as: Cell Rep. 2021 Sep 21;36(12):109735. doi: 10.1016/j.celrep.2021.109735

Figure 7. Increasing length of the LTR region upstream of the tandem NF-κB sites.

Figure 7.

(A) Sequence of the US-NF-κB-II region in the HIV-1 HXB2 reference strain.

(B and C) Length of the region corresponding to the US-NF-κB-II sequence shown in (A) in 2,347 sequences from subtype B and 2,367 sequences from clade C HIV-1-infected individuals (one viral sequence from each person) obtained in the years indicated.

(D) Changes in the length of US-NF-κB-II region (left) and the number of potential NF-κB (middle) and RBEIII sites (right) in the US-NF-κB-II region in subtype B (upper) and C (lower) LTRs. Asterisk (*) indicates that the actual number is one higher because the highly conserved NF-κB-I site is not included in the region analyzed (see A). For clade C, no sequences were available before 1985, and just five sequences were available for the 1986–1990 period.

See also Figure S5.