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. 2021 Sep 28;8:744194. doi: 10.3389/fmed.2021.744194

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Copyright © 2021 Chen, Lai, Yu, Chen, Hsieh, Hsu and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trial profile. 42 patients were randomized into TCM and placebo group in a ratio of 2:1. In the TCM group, 28 patients received 6 grams of Gan Lu Yin after breakfast, and 6 g of Jia Wei Xiao Yao San combined with 1 g of Suan Zao Ren and 1 g of Ye Jiao Teng after dinner in the evening every day. 14 patients orally received placebo with one-tenth dose of TCM's formula and the same appearance every day.