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. 2021 Sep 28;9:731028. doi: 10.3389/fcell.2021.731028

FIGURE 8.

FIGURE 8

Effects of a NOS inhibitor (L-NMMA) and a NO donor, sodium nitroprusside (SNP) on in vitro BBB TEER and permeability. (A) Normalized TEER and (B) normalized permeability to Dex-70K under control and after treatment of 10 min 1 mA/cm2 DCS (DCS), or treatment of 60 min 1 mM L-NMMA, or pretreatment of 60 min 1 mM L-NMMA and treatment of 10 min 1 mA/cm2 DCS (L-NMMA DCS), or treatment of 30 min 300 μM SNP (SNP). n = 6 samples for each case in (A,B). *p < 0.05, compared with the control, @p < 0.05, compared with DCS, #p < 0.05, comparing L-NMMA DCS and SNP with L-NMMA, %p < 0.05, comparing SNP with L-NMMA DCS. The in vitro BBB was formed by hCMEC monolayer.