Table 12.

Coagulopathy manifestation of COVID 19.

Coagulopathy manifestations	References	Sample size	Affected patients	Incidence
Effect on endothelial integrity that can induced venous thrombo embolic disease VTE as DVT and PE	Nägele, Matthias P et al. “Endothelial dysfunction in COVID-19: Current findings and therapeutic implications.” Atherosclerosis vol. 314 (2020): 58-62. doi: 10.1016/j.atherosclerosis.2020.10.014	Review
	Middeldorp, Saskia et al. “Incidence of venous thromboembolism in hospitalized patients with COVID-19.” Journal of thrombosis and haemostasis : JTH vol. 18,8 (2020): 1995-2002. doi: 10.1111/jth.14888	198	Venous thromboembolism in 39 patients	20%
			DVT in 26 patients	13 %
			Symptomatic VTE in 25 patients	About 13%
High D dimer	Li, Y., Zhao, K., Wei, H., Chen, W., Wang, W., Jia, L., Liu, Q., Zhang, J., Shan, T., Peng, Z., Liu, Y., & Yan, X. (2020). Dynamic relationship between D-dimer and COVID-19 severity. British journal of haematology, 190(1), e24–e27. doi: 10.1111/bjh.16811	279	140 patients	123 patients had much elevation in D dimer with poor prognosisAnd 23 patients had improved
Low platelet	Zhao, Xiaofang et al. “Early decrease in blood platelet count is associated with poor prognosis in COVID-19 patients-indications for predictive, preventive, and personalized medical approach.” The EPMA journal, vol. 11,2 1-7. 14 May. 2020, doi: 10.1007/s13167-020-00208-z	532 all COVID 19 patients and all have low platelet on admission time	29 died [the platelet had no increase after the admission]	5.45 %
DIC	Seitz, Rainer, and Wolfgang Schramm. “DIC in COVID-19: Implications for prognosis and treatment?.” Journal of thrombosis and haemostasis : JTH vol. 18,7 (2020): 1798-1799. doi: 10.1111/jth.14878	Letter to editor