FIGURE 3.

Assessment of exploratory behavior and association between nose-poking and water reward in HET mice. Adaptation phase was divided in spontaneous activity (SA) and nose-poke (Np) subphases, where the following parameters were assessed in the male cohort (n = 9/genotype) and the female cohort (n = 8 WT and 10 HET): (A,E) Number of visits/h; (B,F) proportion of visits with nosepokes and visits with licks; (C,G) mean number of nosepokes during visits with nosepokes and without licks; (D,H) median number of licks per visit. No genotype effects were observed in the male dataset. By contrast, female HET animals made significantly more visits compared to their WT littermates (F₁,₃₁ = 9.35, p = 0.0045) Data in panels (B,F) were analyzed by two-way ANOVA. Remaining data were analyzed and plotted with FlowR software. All data are presented as mean ± SEM.