FIGURE 4.

Assessment of learning performance and cognitive flexibility in HET mice. Place learning module was divided in two phases, Acquisition and Reversal, where the percentage of correct responses (visits to the correct corner) was used to evaluate learning performance of the male (n = 9/genotype) and the female (n = 8 WT and 10 HET) cohorts. (A,B) HET male mice displayed a reduced proportion of correct responses compared their WT littermates in Acquisition (A) (F₁,₁₅ = 12.35, p = 0,003128) and Reversal (B) (F₁,₁₅ = 11.97, p = 0,003496). (C,D) Cumulative visits at the correct corner in Acquisition (C) and Reversal (D). (E) Averaged proportion of correct responses by the female cohort in Acquisition and Reversal phases, where no genotype effects were observed. (F) Cumulative visits at the correct corner by the female cohort in Acquisition and Reversal. Data were analyzed and plotted with FlowR software. Data in panels (A,B,E) presented as mean ± SEM. Dotted line on each graph indicates random expectation.