FIGURE 2.

The influence of melatonin on the migration and invasion of OS cells. (A–C) The effects of melatonin on the migration ability of OS cells were detected by wound healing assay. (D–F) The functions of melatonin in the metastasis of OS cells were determined by attachment assay and detachment assay. (G‐I) The roles of melatonin in the cell invasion were assessed by Transwell assay. Scale bar = 200 μm. Significant difference relative to control group was presented as *p < 0.05; **p < 0.01 and ***p < 0.001