FIGURE 6.

Melatonin inhibited the biological functions of OS cells by suppressing lncRNA JPX. (A) The reduced cell viability caused by melatonin treatment was reversed by overexpression of lncRNA JPX. (B) The decreased cell proliferation induced by melatonin was blocked by lncRNA JPX transfection. (C) Melatonin‐induced decrease in the invasion ability of OS cells was turned over in the presence of lncRNA JPX. (D) The attenuated migration of OS cells, which was caused by 1.5 mM melatonin, was partially reversed after lncRNA JPX transfection. (E and F) The attachment assay and detachment assays of OS cells in the presence of melatonin and lncRNA JPX. Scale bar = 250 μm. Significant difference relative to control group was presented as *p < 0.05; **p < 0.01 and ***p < 0.001