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B cells in the synovium of RA. LTα and LTβ secreted by B cells are very important for maintaining the aggregated T cell and B cell infiltrate in the synovial tissue of RA patients. FcRL4+B cells, CD27+IgD-B cells and CD21-/low B cells are prone to produce RANKL, which are pathogenic B cells in the synovium of RA patients. LTα, lymphotoxinα; LTβ, lymphotoxinβ; AID, Activation-induced cytidine deaminase; CXCL, C-X-C motif chemokine ligand; FcRL4, Fc receptor-like 4.
