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. 2021 Sep 28;12:727585. doi: 10.3389/fphys.2021.727585

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Copyright © 2021 Brown, Davis, Fogarty and Sieck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Scatterplot showing that mean mitochondrial volume in type I (circles) and IIa (squares) DIAm fibers is unchanged between 6-month (purple) and 24-month (green) Fischer 344 rats. Mitochondrial volume in type IIx/IIb (triangles) DIAm fibers was significantly lower in 24-month compared with 6-month rats (two-way ANOVA, *P < 0.05). (B) Scatterplot of the mean mitochondrial volume density of type I, type IIa, and type IIx/IIb fibers. There were no differences in mitochondrial volume densities between type I and IIa fibers at either age. Mitochondrial volume density in type IIx/IIb fibers was lower than that of type I or IIa fibers at both ages and was significantly reduced in 24-month compared with 6-month rats (two-way ANOVA, *P < 0.05). (C) Scatterplot showing that mean mitochondrial branch length (μm) in type I and IIa fibers was similar at both ages and was not different between 6-month and 24-month rats. Mitochondrial branch length in type IIx/IIb fibers was shorter than that in type I and IIa fibers at both ages. In addition, mitochondrial branch length in type IIx/IIb fibers was reduced in 24-month compared with the 6-month rats (two-way ANOVA, *P < 0.05). (D) Scatterplot showing mean DIAm fiber mitochondrial complexity index (MCI). The MCI was similar between type I and IIa fibers and did not change with age. The MCI of in type IIx/IIb DIAm fibers was lower than that of type I and IIa fibers at both ages. In addition, the MCI in type IIx/IIb DIAm fibers was reduced in 24-month compared with the 6-month rats (two-way ANOVA, *P < 0.05). # indicated difference between type IIx/IIb fibers and type I and IIa fibers of all ages.