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. 2021 Sep 28;11:737152. doi: 10.3389/fonc.2021.737152

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Copyright © 2021 Wang, Zhang, Wang, Sun, Luo, Jin, Li, Pan and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The global expression profiles of human lung cancer cells/tissues and adjacent lung normal cells/tissues. (A) The first two principal components plot of LUAD tissues via PCA. (B) Volcano plot of genes between human lung cancer tissues and adjacent lung normal tissues. The absolute FC of ≥2.0 and p-value of ≤0.05 were used. (C) Venn diagram plot of DEGs based on tissues and cells with the absolute FC of ≥ 2.0 and p-value of ≤ 0.05. (D) Bubble diagram plot of the top 15 enriched biological processes for the upregulated (left) and downregulated (right) DEGs. (E) Bubble diagram plot of the top 15 enriched KEGG pathways for the upregulated (left) and downregulated (right) DEGs.