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. 2021 Sep 28;13:713084. doi: 10.3389/fnagi.2021.713084

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Copyright © 2021 Lüth, Wasner, Klein, Schaake, Tse, Pereira, Laß, Sinkkonen, Grünewald and Trinh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial CpG methylation frequency detected by Nanopore sequencing in eight individuals. Radar chart showing mitochondrial DNA methylation from eight blood-derived DNA samples detected by Nanopolish. Methylation frequency is indicated by blue spikes. 12S, small subunit rRNA; 16S, large subunit rRNA; ND1, NADH dehydrogenase, subunit 1; ND2, NADH dehydrogenase, subunit 2; COI, cytochrome c oxidase, subunit 1; COII, cytochrome c oxidase, subunit 2; ATPase8, ATP synthase, subunit 8; ATPase6, ATP synthase, subunit 6; COIII, cytochrome c oxidase, subunit 3; ND3, NADH dehydrogenase, subunit 3; ND4L, NADH dehydrogenase, subunit 4L; ND4, NADH dehydrogenase, subunit 4; ND5, NADH dehydrogenase, subunit 5; ND6, NADH dehydrogenase, subunit 6; Cyt b, cytochrome b; D-Loop, displacement loop.