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. 2021 Sep 28;13:713084. doi: 10.3389/fnagi.2021.713084

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Copyright © 2021 Lüth, Wasner, Klein, Schaake, Tse, Pereira, Laß, Sinkkonen, Grünewald and Trinh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial and 45S rRNA CpG methylation comparison by strand. (A) Correlation between the methylation frequency of the mitochondrial plus- and minus-strand (plus-strand = light-strand, minus-strand = heavy-strand). Data of the six blood-derived samples combined. (B) Correlation between the methylation frequency detected from the 45S rRNA gene plus- and minus-strand. Data of the six blood-derived samples combined. r, Spearman's rank correlation coefficient; p, Spearman's exploratory p-value.