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. 2021 Sep 28;13:713084. doi: 10.3389/fnagi.2021.713084

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Copyright © 2021 Lüth, Wasner, Klein, Schaake, Tse, Pereira, Laß, Sinkkonen, Grünewald and Trinh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of mtDNA CpG methylation between patients with Parkin-PD and healthy controls. (A,B) The bar plot shows the mtDNA CpG methylation from blood-derived DNA in patients with Parkin-PD and healthy control subjects, which was either detected with Nanopolish (A) or Megalodon (B). (C,D) The bar plot shows the mtDNA CpG methylation from neuron-derived DNA (iPSC-derived midbrain neurons) in patients with Parkin-PD and healthy control subjects, which was either detected with Nanopolish (A) or Megalodon (B). Bars indicate means and 95% confidence interval. The asterisks represent the level of significance (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001), p-value = Mann Whitney U-test performed for pairwise comparisons, Parkin++ = Parkin biallelic; PD+ = PD patient, patients are indicated in green and control subjects in gray.