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. 2021 Jun 15;41(11-12):1222–1239. doi: 10.1177/03331024211018137

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© International Headache Society 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Funnel-plot of studies addressing mABs, TPM and BoNTA for the prevention of migraine.

(a) Results for mABs. There were fewer studies with higher standard error showing little or no benefit regarding 50% response rate leading to slight asymmetry in the funnel plot. Overall, published studies were consistently positive. (b) Results for TPM. No studies were published with a negative outcome regarding the 50% response rate. Data is skewed by the study of Silvestrini et al. 2003⁴⁹ with a Logs Odds Ratio of 3.48. This study showed an unexpected low placebo response. (c) Results for BoNTA. There were fewer studies published with a negative outcome regarding the 50% response rate compared to placebo. Studies with a lower standard error were published equally independent of outcome.