FIGURE 4.

Expression of functional mediators in regulatory T cells (T_regs). (a) Comparisons of median fluorescence index (MFI) of transforming growth factor (TGF)‐β, interleukin (IL)‐10, and cytotoxic T lymphocyte antigen (CTLA)‐4 in CD4⁺CD25⁺forkhead box protein 3 (FoxP3⁺) cells collected from patients with acute acute adult‐onset Still’s disease (AOSD) and healthy controls (HC). (b) (Left panel) Representative histograms of FoxP3 expression in CD4⁺CD25⁺ cells from patients with AOSD and HC (right bar graph). Comparison of the MFI for FoxP3 in CD4⁺CD25⁺ cells from patients with acute AOSD and HC. (c) Differences in the MFI of FoxP3 in CD4⁺CD25⁺ cells from 11 patients with AOSD collected in the acute and remission phases. (d) Regression analyses of MFI and frequency of IL‐17 in MFI⁻FoxP3 in CD4⁺CD25⁺ cells from patients with acute AOSD. The Mann–Whitney U‐test was used for comparisons between the acute AOSD patients and the HC. Wilcoxon’s signed‐rank test was used for comparisons between acute and remission phases in 11 AOSD patients. **p < 0.005, ***p < 0.0001; NS = not significant