TABLE 2.
Frequencies of intracellular cytokines in Tregs in patients with acute AOSD, remission AOSD and healthy controls
| Acute AOSD (n = 27) | Remission AOSD (n = 11) | HC (n = 16) | p value | ||
|---|---|---|---|---|---|
| */** | |||||
| In CD4+CD25+FoxP3+ cells | |||||
| %IFN‐γ | 24.18 ± 14.92 | 5.20 ± 9.61 | 4.33 ± 3.64 | 0.004/<0.0001 | |
| %IL‐17 | 23.58 ± 21.15 | 1.20 ± 1.36 | 1.84 ± 2.19 | 0.003/<0.0001 | |
| %IL‐4 | 26.97 ± 23.27 | 0.78 ± 1.41 | 2.04 ± 2.15 | 0.003/<0.0001 |
Data are presented as mean ± standard deviation (SD).
Abbreviations: FoxP3, forkhead box protein 3; HC, healthy controls; IFN‐γ, interferon‐γ; IL, interleukin; Tregs, regulatory T cells.
*
Comparisons between acute and remission phases in 11 acute adult‐onset Still’s disease (AOSD) patients using Wilcoxon’s signed‐rank test.
**
Comparisons between 27 acute AOSD patients and 16 HC using the Mann–Whitney U‐test. A p value less than 0.05 was considered statistically significant.