TABLE 3.
Serum cytokine levels in patients with acute and remission AOSD and healthy controls
| Acute AOSD | Remission AOSD | HC | p value | |
|---|---|---|---|---|
| Cytokines | (n = 27) | (n = 11) | (n = 16) | */** |
| IL‐4 (pg/ml) | 13.1 ± 6.1 | 8.7 ± 2.1 | 8.5 ± 2.0 | 0.102/0.033 |
| IL‐6 (pg/ml) | 109.7 ± 139.4 | 11.7 ± 20.3 | 1.7 ± 0.6 | 0.005/<0.0001 |
| IL‐12 (pg/ml) | 1.5 ± 0.5 | 1.8 ± 1.0 | 0.7 ± 0.2 | 0.726/<0.0001 |
| IL‐17 (pg/ml) | 32.3 ± 17.6 | 23.3 ± 2.8 | 21.5 ± 4.1 | 0.368/0.025 |
| IL‐18 (pg/ml) | 2039.4 ± 779.6 | 351.6 ± 286.6 | 72.0 ± 11.1 | <0.0001/<0.0001 |
| IL‐21 (pg/ml) | 26.6 ± 41.2 | 8.4 ± 1.5 | 9.2 ± 1.8 | <0.0001/<0.0001 |
| IFN‐γ (pg/ml) | 75.3 ± 167.3 | 3.3 ± 2.0 | 2.3 ± 3.2 | <0.0001/<0.0001 |
Data are presented as the mean ± standard deviation (SD).
Abbreviations: HC, healthy controls; IL, interleukin; IFN‐γ, interferon‐γ.
*
Comparisons between acute and remission phases in 11 acute adult‐onset Still’s disease (AOSD) patients using Wilcoxon’s signed‐rank test.
**
Comparisons between 27 acute AOSD patients and 16 HC using the Mann–Whitney U‐test. A p value less than 0.05 was considered statistically significant.