TABLE 5.

Association of microbial communities with overall survival of proximal and distal CRCs.

Microbial communities	OS in proximal CRC patients (months)			OS in distal CRC patients (months)
	High	Low/negative	p-Value	High	Low/negative	p-Value
Firmicutes	44.7	48.3	0.185	42.8	39.5	0.356
Bacteroidetes	43.7	47.5	0.305	42.8	37.4	0.639
Proteobacteria	48.3	45.0	0.347	37.0	38.2	0.473
Cyanobacteria	46.6	45.8	0.847	38.6	37.2	0.552
Acidobacteria	46.4	47.1	0.596	37.8	41.9	0.063
Deferribacteres	46.8	46.6	0.673	45.3	45.8	0.129
Elusimicrobia	44.8	46.9	0.467	46.1	40.5	0.238
Nitrospirae	44.2	47.5	0.618	37.8	42.7	0.237
OD1	51.8	45.6	0.068	40.6	41.1	0.855
Planctomycetes	46.7	46.4	0.678	41.5	32.3	0.830
Tenericutes	45.7	46.8	0.881	43.4	41.3	0.789
TM7	46.9	46.1	0.947	46.8	40.9	0.136
Verrucomicrobia	45.3	46.6	0.791	39.8	41.3	0.991
WPS2	47.1	46.5	0.985	45.5	40.4	0.269
Fusobacteria	26.6	38.5	0.005**	29.5	34.7	0.789

We define the level of microflora (high and low/negative) based on the median abundance of microbiota in tumor tissues.

OS, overall survival; CRC, colorectal cancer. *p < 0.05; **p < 0.01.