Table 4.

Comparison of good responders and poor responders, in terms of change in mean AUC (E3%s), post each cycle of NACT compared with baseline (pre-NACT)

Time point comparison	Change in AUC (E3%s) from pre-NACT to third cycle of NACT				Comparison of the two groups in terms of difference of AUC (E3%s) from pre-NACT to follow-up NACT cycles
	Good responder		Poor responder
	Mean (SD) of absolute change	Mean (SD) of % change	Mean (SD) of absolute change	Mean (SD) of % change	p-value of absolute change	p-value of % Change
Post first cycle - pre-NACT	−2.15 (3.61)	−1.1% (85.9)	−1.29 (4.87)	45.0% (130.0)	0.752	0.411
Post second Cycle - pre-NACT	0.12 (3.99)	53.3% (114.8)	−0.37 (3.93)	67.9% (121.7)	0.916	0.689
Post third cycle - pre-NACT	2.77 (6.35)	103.4% (139.0)	1.41 (2.51)	96.1% (95.4)	0.784	0.817

AUC, area under the curve; NACT, neoadjuvant chemotherapy; SD, standard deviation.